Table 3.
Percent analgesic activity (peripheral, writhing test).
| Compd. No. | Percent protection | |||
|---|---|---|---|---|
| 30 min | 1 hours | 2 hour | 3 hours | |
| Visnagen | 39.20 ± 1.20 * | 44 ± 1.10 * | 48.1 ± 1.70 | 32.20 ± 1.25 * |
| Khellin | 40.7 ± 1.65 * | 46 ± 1.35 * | 49.4 ± 1.70 | 33.9 ± 1.10 * |
| 1a | 42.6 ± 1.40 * | 52 ± 1.25 * | 50.4 ± 1.60 | 35.8 ± 1.39 * |
| 1b | 45.0 ± 1.90 * | 53 ± 1.40 * | 55.6 ± 1.38 | 36.3 ± 1.20 * |
| 2a | 46.5 ± 1.50 * | 50 ± 1.10 ** | 52.2 ± 1.30 | 37.5 ± 1.30 * |
| 2b | 48.2 ± 1.55 * | 52 ± 1.20 * | 54.3 ± 1.25 | 38.7 ± 1.40 * |
| 3a | 54.6 ± 1.40 * | 58 ± 1.25 * | 62.6 ± 1.20 * | 46.4 ± 1.10 * |
| 3b | 50.3 ± 1.35 * | 54 ± 1.10 * | 56.4 ± 1.35 | 40.5 ± 1.35 * |
| 3c | 55.8 ± 1.50 * | 59 ± 1.20 * | 63.6 ± 1.30 * | 47.3 ± 1.30 * |
| 3d | 52.6 ± 1.35 * | 56 ± 1.05 * | 58.6 ± 1.35 | 42.1 ± 1.40 * |
| 4a | 60.4 ± 1.40 ** | 63 ± 1.50 ** | 67.7± 1.70 ** | 48.4 ± 1.55 * |
| 4b | 58.5 ± 1.20 * | 60 ± 1.30 * | 65.4 ± 1.55* | 46.5 ± 1.35 * |
| 4c | 61.5 ± 1.50 ** | 64 ± 1.55 ** | 68.8 ± 1.80 ** | 49.5 ± 1.60 * |
| 4d | 59.6 ± 1.30 * | 62 ± 1.40 * | 66.1 ± 1.60 * | 47.3 ± 1.50 * |
| 5a | 66.50 ± 1.20 ** | 68 ± 1.55 ** | 70.6 ± 1.30 ** | 54.5 ± 1.10 * |
| 5b | 62.50 ± 1.40 ** | 65 ± 1.35 ** | 69.10 ±1.25 ** | 52.1 ± 1.30 * |
| 5c | 68.10 ± 1.25 ** | 70 ± 1.85 ** | 71.8 ± 1.35 ** | 55.4 ± 1.05 * |
| 5d | 65.40 ± 1.10 ** | 67 ± 1.50 ** | 70.20 ±1.15 ** | 53.2 ± 1.20 * |
| 6a | 69.60 ± 1.55 ** | 72 ± 1.90 ** | 74.3 ± 1.50 ** | 58.8 ± 1.20 * |
| 6b | 69.1 ± 1.45 ** | 70 ± 1.80 ** | 72.6 ± 1.40 ** | 56.3 ± 1.10 * |
| 6c | 69.80 ± 1.60 ** | 73 ± 1.95 ** | 75.5 ± 1.55 ** | 59.8 ± 1.19 * |
| 6d | 69.4 ± 1.50 ** | 71 ± 1.85 ** | 73.5 ± 1.45 ** | 57.5 ± 1.15 * |
| 7a | 74.4 ± 1.10 ** | 77.5 ± 1.30 ** | 78.3 ± 1.20 | 64.4 ± 1.25 ** |
| 7b | 70.1 ± 1.01 ** | 75.3 ± 1.50 ** | 76.5 ± 1.25 | 62.4 ± 1.20 ** |
| 7c | 75.6 ± 1.20 ** | 78.4 ± 1.40 ** | 79.5 ± 1.35 | 65.6 ± 1.30 ** |
| 7d | 72.2 ± 1.05 ** | 76.2 ± 1.45 ** | 77.6 ± 1.30 | 63.5 ± 1.35 ** |
| Control | 02.0 ± 0.36 | 05.0 ± 0.50 | 04.0 ± 0.58 | 04.0 ± 0.90 |
| Diclfenac sodium | 45.0 ± 0.96 * | 54.3 ± 1.18 * | 61 ± 1.50 * | 38 ± 1.14 * |
Each value represents the mean ± S.E (n = 6).Significance levels * p < 0.5, ** p < 0.001 as compared with respective control. Dose (20 mg/kg). For the selected tested compound .Drug in peripheral analgesic activity testing. The remaining compounds have the same activity in Peripheral analgesic activity testing.