Table 1.

Inhibitory potential of tannins, related molecules as well as other known PARG inhibitors in enzymatic in vitro assays.

Compound				IC50 (µM)	Reference
Hydrolyzable tannins
	Gallotannins
		Trigalloylglucose		33.4 ± 3.1	[56]
				31.8 ± 2.8	[55]
			3-galloyl-α,β-D-glucose	0.95 ± 0.02	[58]
			3-galloyl-O-methyl-α,β-D-glucose	7.1 ± 0.05	[58]
			2-galloyl-O-methyl-α,β-D-glucose	7.2 ± 0.03	[58]
		Tetragalloylglucose		24.8 ± 2.0	[56]
				24.2 ± 1.9	[55]
		Pentagalloylglucose		17.8 ± 1.2	[56]
				18.9 ± 1.1	[55]
	Gallotannin mix			16.8 ± 28.9	[54]
	Ellagitannins
		Monomer
			Tellimagrandin I	10.8 ± 0.6	[56]
				11.9 ± 0.5	[55]
			Casuarictin	13.3 ± 0.7	[56]
				11.7 ± 0.6	[55]
			Geraniin	18.4 ± 0.7	[56]
				15.5 ± 0.6	[55]
		Dimer
			Cornusiin A	5.1 ± 0.2	[56]
				7.1 ± 0.3	[55]
			Rugosin D	5.8 ± 0.3	[56]
				6.1 ± 0.4	[55]
			Coriariin A	8.1 ± 0.5	[56]
				8.5 ± 0.5	[55]
			Nobotanin B	4.8 ± 0.4	[56]
				4.4 ± 0.3	[55]
				15	[57]
			Oenothein B	4.8 ± 0.4	[55]
				3.8	[57]
		Trimer
			Nobotanin E	1.4 ± 0.2	[56]
				1.8 ± 0.2	[55]
		Tetramer
			Nobotanin K	0.44 ± 0.03	[56]
				0.38 ± 0.03	[55]
	Ellagitannin mix			8.3 ± 12.5	[54]
Condensed tannins
	(-)-Epicatechin gallate
		Monomer		>100	[56]
				>100	[55]
		Dimer		>100	[56]
				>100	[55]
		Trimer		>100	[56]
				>100	[55]
		Tetramer		>100	[56]
				>100	[55]
Related compounds
Gallic acid				>100	[56]
Ellagic acid				>100	[56]
(-)-Epicatechin				>100	[55]
(-)-Epigallocatechin				>100	[55]
Benzoic acid				>100	[54]
Glucose				>100	[56]
Other PARG inhibiting molecules
ADP-HPD				0.33	[59]
				0.136	[60]
				0.66	[61]
				0.12	[62]
N-bis-(3-phenylpropyl)-9-oxofluorene-2,7-diamide (GPI16552)				1.7	[63]
Eosin Y				1.9	[61]
GPI18214				3	[64]
Phloxine B				5	[61]
Ethacridine				7.2	[60]
Adenosine cyclic 3’, 5’-monophosphate				300	[65]
ADP-ribose				3200	[57]
				1100	[65]