Table 2.

Examples of MEDI-HPS indications in need of adjustment and clarification

Drug	MEDI Indication	SPL indication
Denosumab	Malignant neoplasm of prostate	Treatment to increase bone mass in men at high risk for fracture receiving androgen deprivation therapy for nonmetastatic prostate cancer
Vancomycin	Other and unspecified noninfectious gastroenteritis and colitis	Treatment of serious or severe infections caused by susceptible strains of methicillin-resistant (betalactam-resistant) staphylococci
Lamotrigine	Rash and other nonspecific skin eruption	Epilepsy and bipolar disorder
Benzocaine	Infective otitis externa, unspecified	Relief of pain and reduction of inflammation
Morphine	Acute myocardial infarction, unspecified site; episode of care unspecified	Relief of moderate to severe acute and chronic pain
Orlistat	Diabetes mellitus	Obesity management, including weight loss and weight maintenance
Sargramostim	Myeloid leukemia, acute	Prevention of neutropenia from chemotherapy