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Roles of circRNAs. (A) Aberrant circRNAs expression associates with different cancer outcome. (B) Immune signaling, such as Toll-like receptor, induces the production of host circRNAs (left). Foreign circRNAs evoke RIG-I mediated immune responses via intron identity (right). (C) CircRNAs expression associates with cellular functions. (D) Hypoxia induces circRNAs expression.
