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. 2018 Nov 13;476(12):2442–2453. doi: 10.1097/CORR.0000000000000548

Fig. 7.

Fig. 7

This diagram illustrates the current working model. Priming of the NLRP3 inflammasome by wear particles depends on adherent PAMPs and their cognate TLRs (blue). Activation of the NLRP3 inflammasome by wear particles does not depend on adherent PAMPs (green). See text for details.