Figure 2.

Quantification of angiogenesis in the midgestational placental labyrinth of wild-type (Fshr^+/+) and null (Fshr^−/−) fetuses. The (A) number and (B) size of fetal sinuses, and the (C) number and (D) size of maternal sinuses in Fshr^+/+ and Fshr^−/− labyrinths of placentas 15 days post coitus, with number of sinuses normalized to overall labyrinth size. Data shown are the mean ± SEM of sinus quantifications of three Fshr^+/+ and six Fshr^−/− placentas. *P < 0.05. [Reproduced with permission from Stilley JAW, Segaloff DL. Deletion of fetoplacental Fshr inhibits fetal vessel angiogenesis in the mouse placenta. Mol Cell Endocrinol. 2018;476:79–83.]