Table 4.
Univariate and multivariate logistic regression analysis for the predictors of mortality among HCC group
| Variable | No. | Univariate | Multivariate logistic regression | |||
|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | |||
| Child-Pugh | A | 45 | R | |||
| B/C | 60 | 3.5 (0.92–13.5) | 0.053 | – | – | |
| MELD | ≤38 | 72 | R | |||
| >38 | 33 | 1.56 (0.5–4.8) | 0.55 | – | – | |
| AFP (ng/dl) | <100 | 75 | R | |||
| >100 | 30 | 16 (4.1–62.7) | <0.001(HS) | 9.62 (2.2–41.8) | 0.003 (S) | |
| Endocan (pg/ml) | <4000 | 72 | R | |||
| ≥4000 | 33 | 13.1 (3.3–51.0) | <0.001(HS) | 8.5 (1.8–30.8) | 0.017 (S) | |
| VEGF (pg/dl) | <2906 | 66 | R | |||
| ≥2906 | 39 | 3 (0.98–9.2) | 0.08 | – | – | |
| Okuda staging | I/II | 87 | R | |||
| III/IV | 18 | 1.3 (0.31–4.97) | 0.72 | – | – | |
| Size (cm) | ≤3 cm | 51 | R | |||
| >3 cm | 54 | 4.6 (1.2–17.3) | 0.017 (S) | 2.34 (1.2–6.5) | 0.024 (S) | |
| T number | Single | 48 | R | |||
| Multiple | 57 | 1.3 (0.43–3.99) | 0.78 | – | – | |
| AFP-Endocan | 0/1 | 87 | R | R | ||
| 2 | 18 | 35 (6.9–68.5) | <0.001 (HS) | 27.4 (1.9–44.5) | 0.023 (S) | |
| AFP-VEGF | 0/1 | 93 | R | R | ||
| 2 | 12 | 23.5 (5.1–63.2) | 0.001 (HS) | 13.8 (2.5–50.1) | 0.013 (S) | |
| AFP-Endocan-VEGF | 0/1 | 87 | R | R | ||
| 2/3 | 18 | 35 (6.9–68.5) | <0.001 (HS) | 27.4 (1.9–44.5) | 0.023 (S) | |
Note: The bold values represent significant values.
Abbreviations: AFP, 〈-fetoprotein; HCC, hepatocellular carcinoma; HS, highly significant; MELD, Model for End-stage Liver Disease; R, reference; S, significant; VEGF, vascular endothelial growth factor.