Table 2.

Non-compartmental analysis of trastuzumab PK profiles.

	Plasma	Brain	ISFST	CSFLV	CSFCM
$AU{C}_{0\to t_{last}}\left(nmole\cdot h\cdot L^{-1}\right)$	168358 (9762a)	451.3 (33.8)	1006 (116)	690.7 (73.1)	875.8 (156)
$AU{C}_{plasma}/AU{C}_{sample}$	1	373	167	244	192
$\frac{AU{C}_{sample}}{AU{C}_{plasma}}\cdot 100\left(\mathrm{\%}\right)$	100	0.27	0.60	0.41	0.52
$C_{max}$($nmole\cdot L^{-1}$)	2206b	2.36	3.08	3.04	3.1
$t_{max}$($h$)	0	14	24	24	24
$t_{1/2}$ ($h$)	134	105	148	115	180

a: standard deviation derived by modified Bailer method in WinNolin 7.0

b: extrapolation to the time zero

Abbreviations: ISF_ST: interstitial fluid at the striatum; CSF_LV: cerebrospinal fluid within the lateral ventricles; CSF_CM: cerebrospinal fluid within the cisterna magna; $AU{C}_{0\to t_{last}}$: areas under the concentration vs time curves from time zero to the last time point; $C_{max}$: the maximum concentration; $t_{max}$: time to the maximum concentration; $t_{\frac{1}{2}}:$ half-life in the terminal phase