Table 2.
Structural features of anti-hapten sdAb paratopes.
| Antigen | sdAb Type | CDR3 Length (aa) |
CDR1/2 Canonical Structures |
Paratope MSA (Å2) |
Paratope Diameter (Å) |
CDR Loop Extension (Å) | Reference |
|---|---|---|---|---|---|---|---|
| Reactive Red 6 | VHH | 17 | H1-13–1, H2-15–1 | 4380 | 14.7 | 17.8 (CDR1), 22.8 (CDR2), 22.3 (CDR3) | 116 |
| Reactive Red 1 | VHH | 18 | H1-16–1, H2-10–2 | 4242 | 15.0 | 21.8 (CDR1), 22.3 (CDR2), 22.9 (CDR3) | 117 |
| Methotrexate | VHH | 17 | H1-13–11, H2-10–2 | 3866 | 14.7 | 22.4 (CDR1), 17.6 (CDR2), 21.0 (CDR3) | 113 |
| DYEPEA peptide | VHH | 18 | H1-13–11, H2-11-* | 3698 | 14.8 | 16.3 (CDR1), 16.6 (CDR2), 21.8 (CDR3) | 118 |