Table 2.
Akaike Information Criteria for Pharmacokinetic/Pharmacodynamic Indices on Different Sampling Days in the Hollow Fiber System Model of Tuberculosis
| PK/PD Index | Day 7 | Day 14 | Day 21 | Day 28 |
|---|---|---|---|---|
| Microbial kill | ||||
| AUC0–24/MIC | 20.22 | 25.82 | 29.99 | 30.85 |
| Peak/MIC | 35.03 | 36.00 | 36.39 | 37.69 |
| %TMIC | 29.96 | 23.53 | 18.47 | 20.69 |
| Resistance log10 CFU/mL | ||||
| AUC0–24/MIC | –8.37 | –0.35 | 9.30 | 13.44 |
| Peak/MIC | 7.42 | 12.35 | 14.81 | 16.89 |
| %TMIC | 11.62 | 5.69 | 8.94 | –0.23 |
Values in bold indicate the PK/PD parameter with the lowest AIC scores for microbial kill and ADR on the different sampling days.
Abbreviations: %TMIC, percentage of time concentration persisting above the minimum inhibitory concentration; AUC0–24, 0- to 24-hour area under the concentration–time curve; CFU, colony-forming units; MIC, minimum inhibitory concentration; PK/PD, pharmacokinetic/pharmacodynamic.