Table 1.
Ethionamide Pharmacokinetic Parameters and Variances
| Pharmacokinetic Parameter | Domain of Input (Mean ± SD) [2, 3] |
10000 Simulated Patients (Mean ± SD) |
US Food and Drug Administration Ethionamide Label Informationa (Mean ± SD) |
|---|---|---|---|
| Clearance, L/h/kg | 1.88 ± 2.26 | 1.92 ± 1.56 | … |
| Volume, L/kg | 3.95 ± 1.20 | 3.93 ± 2.12 | (93.5 ± 19.2)b |
| Absorption constant, hour-1 | 0.25 ± 0.10 | 0.25 ± 0.32 | … |
| 0–24 hour area under the concentration-time curve, mg*h/L for 250 mg | … | 7.14 ± 5.21 | 7.67 ± 1.69 |
| Peak, mg/L for 250 mg | … | 1.42 ± 1.46 | 2.16 ± 0.61 |
Abbreviation: SD, standard deviation.
bData not published in milligrams per kilogram, and patient weight not published.