Table 2.
Effect of Levofloxacin, Moxifloxacin, and Gatifloxacin in Hollow Fiber System Model of Tuberculosis and Monte Carlo Experiments from Different Studies With Similar Experimental Design
| Variables | Moxifloxacin | Gatifloxacin | Levofloxacin |
|---|---|---|---|
| Maximal kill (log10 CFU/mL/day) | 0.57 | 0.68 | 0.61 |
| Time to 1% acquired drug resistance (days) | 10 | 21 | 21 |
| % population resistant at end of experiment | 100 | 5 | 100 |
| Area under the concentration-time curve/minimum inhibitory concentration resistance suppression | 53 | 184 | 360 |
| Exposure associated with 80% of maximal kill | 56 | 184 | 146 |
| Monte Carlo experiment–derived dose (mg/day): resistance suppression | |||
| Pulmonary tuberculosis | 800 | 800 | 1500 |
| Meningeal tuberculosis | - | 1200 | >3000 |