Table 2.
Univariate and multivariate Cox regression analyses for OS time among patients diagnosed with BC with and without PD
| Variables | Crude HR | 95% CI | P-value | Adjusted HR | 95% CI | P-value |
|---|---|---|---|---|---|---|
| Age | ||||||
| <40 | 1 | |||||
| ≥40 | 23.15 | 0.03–19,086 | 0.360 | |||
| Diagnosis | ||||||
| DCIS | 1 | |||||
| IDC | 25.69 | 0.05–12,905.8 | 0.653 | |||
| Cancer stage | ||||||
| 0 + I + II | 1 | 1 | ||||
| III | 4.89 | 2.02–11.87 | <0.01 | 6.95 | 2.81–17.21 | <0.001 |
| Hormone receptor | ||||||
| Negative | 1 | 1 | ||||
| Positive | 0.16 | 0.05–0.56 | 0.004 | 0.23 | 0.06–0.83 | 0.025 |
| HER2 | ||||||
| Negative | 1 | 1 | ||||
| Positive | 2.98 | 1.13–7.81 | 0.027 | 2.29 | 0.82–6.37 | 0.114 |
| Paget’s disease | ||||||
| Without | 1 | 1 | ||||
| With | 4.33 | 1.55–12.11 | 0.005 | 2.63 | 0.88–7.88 | 0.083 |
Note: Bold-faced values are statistically significant (P<0.05).
Abbreviations: BC, breast cancer; DCIS, ductal carcinoma in situ; HR, hazards ratio; IDC, invasive ductal carcinoma; OS, overall survival; PD, Paget’s disease.