Table 2.
Bone mass, microarchitecture, and strength of femur, lumbar vertebral body and tibia.
| Group | Control | GC-only | GC + LLP250 | GC + LLP500 | GC + PTH | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variable (Mean ± SD) | N | N | N | N | N | |||||
| Body weight | ||||||||||
| Initial (g) | 7 | 24.8 ± 1.9 | 14 | 25.6 ± 2.2 | 11 | 25.9 ± 1.2 | 13 | 25.4 ± 1.2 | 10 | 25.4 ± 0.9 |
| Final (g) | 7 | 28.9 ± 1.1b | 14 | 25.4 ± 1.7 | 10 | 24.9 ± 1.5 | 13 | 24.6 ± 1.5 | 10 | 25.4 ± 1.6 |
| Distal femoral epiphysis bone mass and microarchitecture | ||||||||||
| Bone volume | 7 | 0.371 ± 0.109b | 15 | 0.241 ± 0.059 | 7 | 0.196 ± 0.034b | 8 | 0.286 ± 0.058 | 8 | 0.304 ± 0.074b |
| Trabecular number (mm−1) | 7 | 6.74 ± 1.61b | 15 | 9.92 ± 1.75 | 7 | 10.37 ± 1.21 | 8 | 9.44 ± 1.22 | 8 | 10.05 ± 1.57 |
| Trabecular thickness (μm) | 7 | 108.7 ± 39.7b | 15 | 58.1 ± 17.5 | 7 | 49.0 ± 10.1 | 8 | 64.3 ± 8.7 | 8 | 64.2 ± 20.7 |
| Trabecular spacing (μm) | 7 | 47.2 ± 10.2 | 15 | 46.3 ± 8.1 | 7 | 48.7 ± 3.1 | 8 | 43.1 ± 9.3 | 8 | 38.0 ± 4.0b |
| Adipocyte volume | 7 | 0.36 ± 0.24b | 14 | 2.17 ± 1.71 | 12 | 1.16±089b | 13 | 2.60 ± 3.95 | 9 | 1.91 ± 2.01 |
| Distal femoral metaphysis bone mass and microarchitecture | ||||||||||
| Bone volume | 7 | 0.205 ± 0.011 | 15 | 0.189 ± 0.019 | 11 | 0.209 ± 0.029b | 13 | 0.213 ± 0.020b | 10 | 0.251 ± 0.033b |
| Trabecular number (mm−1) | 7 | 4.42 ± 0.31 | 15 | 4.54 ± 0.24 | 11 | 4.72 ± 0.21 | 13 | 4.63 ± 0.32 | 10 | 4.87 ± 0.23b |
| Trabecular thickness (μm) | 7 | 46.94 ± 1.19b | 15 | 43.68 ± 1.89 | 11 | 45.26 ± 2.52b | 13 | 45.95 ± 2.27b | 10 | 50.32 ± 3.19b |
| Trabecular spacing (μm) | 7 | 231 ± 18 | 15 | 223 ± 12 | 11 | 214 ± 10 | 13 | 220 ± 17 | 10 | 209±11b |
| Structure-model index | 7 | 0.804 ± 0.160b | 15 | 1.054 ± 0.218 | 11 | 0.900 ± 0.332 | 13 | 0.875 ± 0.192b | 10 | 0.474 ± 0.303b |
| LVB5 bone mass and microarchitecture | ||||||||||
| Bone volume | 7 | 0.205 ± 0.011 | 15 | 0.189 ± 0.019 | 9 | 0.212 ± 0.032b | 13 | 0.213 ± 0.020b | 9 | 0.245 ± 0.028b |
| Trabecular number (mm−1) | 7 | 4.91 ± 0.22 | 15 | 4.85 ± 0.33 | 9 | 5.20 ± 0.36b | 13 | 5.23 ± 0.29b | 9 | 5.29 ± 0.28b |
| Trabecular thickness (μm) | 7 | 41.6 ± 0.9b | 15 | 38.5 ± 2.3 | 9 | 40.3 ± 3.7 | 13 | 40.5 ± 2.4b | 9 | 46.3 ± 3.3b |
| Trabecular spacing (μm) | 7 | 162 ± 9 | 15 | 169 ± 17 | 9 | 153±17b | 13 | 151±12b | 9 | 143 ± 12bc |
| Bone strength | ||||||||||
| LVB Ultimate Load (N) | 6 | 52.9 ± 7.9b | 15 | 35.8 ± 9.9 | 9 | 42.8 ± 10.2 | 13 | 45.3 ± 10.0b | 10 | 44.0 ± 8.2b |
| CT ultimate load (N) | 7 | 16.64 ± 1.74b | 15 | 13.15 ± 1.00 | 12 | 13.81 ± 1.44 | 14 | 13.73 ± 1.44 | 10 | 13.64 ± 1.40 |
| CT work to failure (N-mm) | 7 | 4.68 ± 1.67b | 15 | 3.19 ± 0.96 | 12 | 3.17 ± 0.96 | 14 | 3.39 ± 1.07 | 10 | 3.60 ± 1.06 |
GC-glucocorticoid; LVB- lumbar vertebral body; CT- Central Tibia.
b
diff from GC-only (P < 0.05).