Table 2.

Criteria and Interpretations of Biochemical Screening Results for Primary Aldosteronism

Criteria	ARR, ng/dL per ng/mL/h	Serum Aldosterone, ng/dL	Plasma Renin Activity, ng/mL/h	Comments
Most conservative	≥40	≥20	≤0.50	Highest risk of missing mild-to-moderate severity cases (i.e., more false-negatives)
Conservative and most widely accepted	≥30	≥15	≤1.0	Some risk of false-negatives
More permissive but less widely accepted	≥20 or ≥25	≥9–10	≤1.0	Some risk of false-positives
Most permissive	≥20	≥6	≤0.50	Highest risk of positive screens that are not true cases (i.e., more false-positives)