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Structural comparison of CON, the Srf A-C condensation domain, the CT domain, and the X domain. They all show a similar V shape fold with a substrate channel running through the protein. The surface structural comparison of CON (orange), the Srf A-C condensation domain (2VSQ, yellow), the CT domain (5DIJ, marine), and the X domain (4TX2, green) shows that conserved resides of HHxxxD motif (white) locate at the midpoint of the substrate channel.
