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. 2018 Sep 11;7(1):115–134. doi: 10.1016/j.jcmgh.2018.08.008

Figure 6.

Figure 6

(A) Immunohistologic staining for NKp46 in Huh-7 cell xenograft tumors of mice in 3 groups (n = 5 for each group) (original magnification, ×200). NIH image analysis software was used to quantify the mean percent area of positive staining for NKp46 for 5 randomly selected fields of view of digital images of each liver. **P < .01. (B) H&E and NKp46 staining of same tissue sections of Huh-7 cell xenograft tumors of mice in 2 groups (original magnification, ×200). Areas surrounded by dotted lines in the H&E images indicate necrotic areas in the tumor tissue. (C) The liver of STAM mice at 18 weeks of age showed multiple liver tumors, whereas the liver of STAM mice administered with sitagliptin showed significantly smaller and fewer liver tumors (n = 5 for each group). *P < .05. (D) Histology of liver tumor showed increased cellular density and/or markedly thickened trabeculae, which were compatible with HCC morphology (original magnification, ×400). (E) and (F) Immunohistologic staining for NKp46 (E) or CD3 (F) in liver tumors and non-tumor liver tissue of STAM mice in 2 groups (n = 5 for each group) (original magnification, ×200). NIH image analysis software was used to count the number of positive staining cells for NKp46 or CD3 for 5 randomly selected fields of view of digital images of each liver. **P < .01.