Table 3.
Effects of Sitagliptin on Biochemical and Histologic NASH-Related Parameters
| Parameters | Control (n = 5) | Sitagliptin (n = 5) | P value |
|---|---|---|---|
| Biochemical parameters | |||
| Glucose (mg/dL) | 435.4 ± 96.8 | 365.4 ± 85.4 | .19 |
| HbA1c (%) | 6.0 ± 0.5 | 5.6 ± 0.8 | .36 |
| Insulin (ng/mL) | 0.17 ± 0.05 | 0.20 ± 0.07 | .55 |
| AST (IU/L) | 104.2 ± 35.6 | 84.0 ± 24.0 | .38 |
| ALT (IU/L) | 115.0 ± 44.1 | 98.4 ± 20.0 | .27 |
| Total cholesterol (mg/dL) | 152.4 ± 5.4 | 142.6 ± 26.1 | .92 |
| Triglyceride (mg/dL) | 409.8 ± 167.6 | 318.0 ± 92.2 | .38 |
| NAFLD activity score | |||
| Steatosis | 2.4 ± 0.9 | 1.6 ± 0.5 | .13 |
| Inflammation | 1.4 ± 0.5 | 1.0 ± 0.0 | .14 |
| Ballooning | 1.4 ± 0.9 | 1.0 ± 1.0 | .53 |
| NAFLD activity score | 5.2 ± 1.5 | 3.6 ± 1.5 | .11 |
ALT, alanine aminotransferase; AST, aspartate aminotransferase; HbA1c, glycosylated hemoglobin.