Figure 6.

Potential Clinical Implications of the TRIM28 and BOK Interrelationship

(A–C) (A) Multiparametric Cox hazard ratio modeling of BOK and TRIM28 mRNA levels in several cancer types. Number of patients (N), 95% confidence interval of the hazard ratio function (HR 95% CI), significance (p value), and overall significance of the model (Model p value) are tabulated. Patients were classified according to their BOK and TRIM28 levels with respect to each gene population median expression into two strata (“high”/“low”) and further analyzed for overall survival (B) and correlation of the two genes within each strata (C). Differences in survival were detected with the log rank test, and correlations were determined using the Spearman's estimate. Significance levels, p > 0.05^ns, p < 0.05*, p < 0.01**, p < 0.001***. See Table S2 for original and full data.