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. 2018 Nov 10;9:475–486. doi: 10.1016/j.isci.2018.11.012

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© 2018 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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MSN1-Dependent Regulation of Third Harmonic Rhythms and Co-regulation of Anti-phasic Genes

(A–D) Heatmaps comparing the expression of the circadian (A) and third harmonic genes (B) (from Figure 1) in the WT and ΔMSN1 strains. The genes are sorted according to their phases in the WT, and a common scale is used for all heatmaps. (C) Competitive gene set testing (Wu and Smyth, 2012) of the different harmonic components in the ΔMSN1 strain within the rhythmic sets identified in the WT strain. Adjusted p-values are rounded up to the four levels shown, and crosses represent no significance (>0.05). (D) The standardized (Z score) expression profiles of the Group 1 (violet) and Group 2 (green) genes in the different genotypes and in the WT dataset from Hurley et al. (2014). The average of the standardized profiles in each group is shown as thick dashed lines. Missing time points were omitted from the plots. See also Figures S4 and S5.