Table 2.
An initial survey of reaction conditions for reaction of indole with benzaldehyde.
| Entry | Temperature (°C) | Catalytic amount (mg) | Mole ratio indole:benzaldehyde | Time (min) | Yielda (%) |
|---|---|---|---|---|---|
| 1 | 100 | 10 | 2:1 | 10 | 30 |
| 2 | 120 | 10 | 2:1 | 10 | 57 |
| 3 | 140 | 10 | 2:1 | 10 | 62 |
| 4 | 160 | 10 | 2:1 | 3 | 83 |
| 5 | 160 | 1 | 2:1 | 10 | 68 |
| 6 | 160 | 5 | 2:1 | 10 | 80 |
| 7 | 160 | 10 | 2:1 | 10 | 98 |
| 8 | 160 | 10 | 3:1 | 10 | 90 |
| 9 | 160 | 10 | 4:1 | 10 | 90 |
Isolated yield.