Table 1.
Clinical and Preclinical Information of Liposarcoma PDCs
| Clinical Information |
Experimental Information |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Patient ID | Sex | Age | SMC |
FNCLCC |
Primary |
Tumor |
Tumor |
MDM2 |
CDK4 |
Ki67 |
Cell |
MDM2 |
In vivo |
PDX |
|
| Dx | Grading | Recurrent | Size (cm) | Location | Histology | Histology | (%) | Passage | FISH | Tumor engraft | Passage | ||||
| 1 | 11GS-013 | F | 54 | DDLPS | 3/3 | 2nd recur | 49×30×11 | Retroperitoneum | Positive | Positive | 10 | p.36 | Positive (100) | 3/3 | G1 |
| 2 | 11GS-018 | M | 75 | DDLPS | 2/3 | primary | 39×34×15 | Retroperitoneum | - | Positive | 30 | p.19 | Positive (100) | 3/3 | G1 |
| 3 | 11GS-079 | M | 71 | DDLPS | 3/3 | 1st recur | 14×13×13 | Kidney and colon | - | Positive | 20 | p.102 | Positive (100) | 5/5 | G1 |
| 4 | 11GS-099 | M | 66 | DDLPS | - | 1st recur | 7×6×5.5 | Kidney Retroperitoneum | Positive | Positive | - | P.59 | Positive (100) | 5/5 | G1 |
| 5 | 11GS-106 | F | 77 | DDLPS | 3/3 | Primary | 18×14×11 9×9×3 |
Kidney | Positive | Positive | 15 | p.43 | Positive (100) | - | - |
| 6 | 14GS-022 | M | 66 | DDLPS | 2/3 | 2nd recur | 8×7 | Retroperitoneum | Positive | Positive | - | p.6 | N.D | 2/8 | G2 |
| 7 | 14GS-026 | F | 77 | DDLPS | 3/3 | 1st recur | 5.7×3×2.5 | back | Positive | Positive | - | p.47 | Positive (100) | 3/3 | G1 |
| 8 | 14GS-032 | F | 49 | DDLPS | 2/3 | Primary | 18×15×10 | Retroperitoneum | Positive | Positive | - | p.27 | Positive(100) | 21/22 | G3 |
| 9 | 14GS-034 | M | 35 | WDLPS | 2/3 | Primary | 42×33×16 | Retroperitoneum | Positive | Positive | - | p.13 | N.D | - | - |
| 10 | 14GS-035 | M | 46 | DDLPS | 2/3 | Primary | 34×24×6 | Intraabdominal and kidney | Positive | Positive | - | p.15 | Positive (100) | - | - |
| 11 | 14GS-054 | F | 52 | DDLPS | 2/3 | 4th recur | 9×7×5 | Retroperitoneum | Positive | Positive | - | p.11 | Positive (37.5) | - | - |
| 12 | 14GS-057 | F | 65 | WDLPS | 1/3 | 3rd recur | 5×4×4 | Retroperitoneum pancreas | Positive | Positive | - | p.9 | Positive (19) | - | - |
| 13 | 14GS-076 | F | 52 | DDLPS | 2/3 | 3rd recur | 16×14×11 11×7×6 |
Small bowel | Positive | Positive | 60 | P27 | Positive (100) | 33/34 | G3 |
| 14 | 14GS-078 | M | 76 | WDLPS | 1/3 | Primary | 18×17×5 | Retroperitoneum | Positive | Positive | - | P9 | Positive (100) | - | - |
| 15 | 14GS-079 | M | 77 | WDLPS | 1/3 | Primary | 30×26×8 5.5×4×2.5 |
Perirenal mass, Retroperitoneum | Positive | Positive | - | P12 | Positive (6) | - | - |
| 16 | 14GS-084 | F | 59 | DDLPS | 2/3 | Primary | 20×19×8.5 | Retroperitoneum | - | - | P17 | N.D | 23/23 | G5 | |
| 17 | 15GS-002 | F | 61 | DDLPS | 3/3 | Primary | 30×16 | Retroperitoneum | Positive | - | 35 | P11 | N.D | 19/19 | G3 |
| 18 | 15GS-006 | M | 67 | DDLPS | 1/3 | 4th recur | 6×6 5×4.2 | Peristomach Kidney | - | - | - | P7 | N.D | - | - |
| 19 | 15GS-022 | M | 56 | WDLPS | 1/3 | 1st recur | 9.8×5×3.5 | Retroperitoneum | - | - | - | P6 | N.D | - | - |
| 20 | 15GS-023 | F | 61 | DDLPS | 3/3 | Primary | 15×8×6 | Retroperitoneum | Postivie | - | 10 | P7 | Positive (76.5) | 15/15 | G2 |