Table 2.
Outcome of the meta-analyses for the comparison between clearing heat and removing dampness method of Chinese traditional medicine and western medicine, according to study design.
| Author, year | Effective number | SUA | CRP | ESR | Adverse reactions | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| EG | CG | EG | CG | EG | CG | EG | CG | EG | CG | |
| Yan Zhang, 2016 | 25 | 23 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Fang Zuo, 2001 | 52 | 22 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Yihui Yan, 2006 | 33 | 28 | 487.27± 98.88/374.88± 95.48 | 469.26± 114.41/414.52± 102.13 | N/A | N/A | N/A | N/A | N/A | N/A |
| Xubin Zhao, 2014 | 25 | 23 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Li Cheng, 2009 | 31 | 29 | N/A | N/A | N/A | N/A | N/A | N/A | 0 | 9 |
| Guicai Sun, 2007 | 58 | 54 | 568.6±21.2/397.2±36.7 | 572.5±27.6/385.8±30.2 | N/A | N/A | 59.2±7.4/17.1±4.6 | 53.7±8.7/15±4.3 | N/A | N/A |
| Yuhong Zhang, 2003 | 39 | 42 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Shengyun Wu, 2017 | 33 | 18 | N/A | N/A | 35.5±3.5/8.9±1.1 | 35.7±3.3/10.1±1.2 | 45.7±9.3/14.6±9.4 | 46.9±9.1/21.8±9.2 | N/A | N/A |
| Qingsheng He, 2016 | 49 | 44 | 511±47.77/370±21.56 | 497±50.12/476±19.57 | 31.34±9.12/8.04±1.29 | 29.77±8.9/9.26±2.55 | 45±11.26/17±6.78 | 47±12.57/21±5.91 | 0 | 5 |
| Lixin Wang, 2001 | 67 | 33 | N/A | N/A | N/A | N/A | N/A | N/A | 0 | 32 |
| Zhonghua Yang, 2007 | 55 | 27 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Wenping Cao, 2008 | 44 | 38 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Yanhong Zou, 2010 | 34 | 32 | 442.15±60.12/399.76±38.27 | 438.58±67.45/417.12±41.45 | 67.12±30.23/33.46±15.23 | 60.58±29.40 | 64.12±25.78/34.28±12.21 | 60.10±23.69/40.79±13.08 | N/A | N/A |
| Jincheng Cai, 2006 | 52 | 43 | 585±155/458±162 | 592±142/587±148 | N/A | N/A | N/A | N/A | N/A | N/A |
| Wei Li, 2016 | N/A | N/A | 536.24±54.16/316.49±48.28 | 529.75±52.67/376.62±35.39 | 32.94±5.84/13.26±8.49 | 33.18±5.63/20.17±9.64 | 24.21±9.64/10.26±5.35 | 23.68±9.71/14.86±5.47 | N/A | N/A |
| Yingxu Wang, 2014 | 31 | 27 | 605.21±132/474.63±85.4 | 601.16±114.2/454.51±92.2 | N/A | N/A | N/A | N/A | N/A | N/A |
| Wei Liu, 2016 | 30 | 29 | 548.25±96.31/394.34±32.69 | 541.45±48.11/46 | N/A | N/A | N/A | N/A | N/A | N/A |
| Feng Yue, 2005 | 30 | 30 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Yanming Ren, 2007 | 52 | 27 | 544.36±86.27/341.25±79.34 | 567.74±91.13/387.32±64.64 | N/A | N/A | 52.61±12.35/28.37±9.36 | 48.22±11.79/42.72±0.24 | N/A | N/A |
| Huilian Wang, 2012 | 34 | 33 | N/A | N/A | 49.7±11.6/18.5±6.4 | 47.6±12.6/18.2±5.7 | 9.0±3.0/3.9±1.2 | 8.9±2.9/4.0±2.0 | N/A | 6 |
| Wei Jin, 2013 | 30 | 24 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Hong Tu, 2015 | 29 | 24 | N/A | N/A | 26.28±7.89/5.47±3.01 | 24.16±6.99/12.12±4.21 | 39.62±16.51/14.71±8.97 | 37.74±14.63/24.07±12.61 | 1 | 5 |
| Binchu Wang, 2000 | 49 | 33 | 489±23.1/345±20.1 | 486±21.5/371±19.1 | N/A | N/A | N/A | N/A | N/A | N/A |
| Haifeng Li, 2012 | 67 | 69 | 287.6±56.4 | 426.1±89.2 | N/A | N/A | 21.1±5.4 | 38.3±10.0 | N/A | N/A |
| Hongtao Yan, 2006 | 18 | 16 | 537.85±39.72/425.3±16.24 | 558.5±31.27/550.8±25.09 | N/A | N/A | 45.30±7.97/40±5.39 | 44.55±8.11/43.95±5.85 | 1 | 8 |
| Weigang Zeng, 2010 | 54 | 32 | N/A | N/A | N/A | N/A | N/A | N/A | 0 | 2 |
| Weigang Zeng, 2007 | 118 | 108 | N/A | N/A | N/A | N/A | N/A | N/A | 0 | 60 |
| Jiang Wu, 2015 | 33 | 30 | 528.46±78.42/436.14±83.27 | 521.47±80.12/446.72±67.46 | 26.24±12.08/10.37±2.58 | 27.18±11.83/12.43±3.19 | 40.72±13.06/16.87±2.26 | 39.24±13.27/24.35±4.03 | 2 | 6 |
| Jing Chen, 2017 | 58 | 47 | 542.15±36.79/384.20±47.28 | 538.76±42.53/437.21±42.13 | N/A | N/A | N/A | N/A | N/A | N/A |
| Minghai Zhou, 2014 | 19 | 15 | N/A | N/A | N/A | N/A | N/A | N/A | 0 | 3 |
| Guangheng Cui, 2011 | 55 | 56 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Yangang Wang, 2005 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Hai Lu, 2013 | 29 | 25 | 564±80.5/326±20.3 | 518±75.4/349±34.7 | 36.1±4.3/14.6±5.6 | 34.2±6.8/18.4±3.9 | 65.7±18.5/22.6±7.3 | 63.4±11.7/29.6±6.9 | 2 | 1 |
| Bo Duan, 2016 | 47 | 46 | 673.31±25.26/421.43±58.90 | 666.42±31.54/432.27±70.11 | 36.83±9.62/15.42±8.94 | 34.56±10.11/17.02±7.78 | 20.52±9.98/8.23±5.83 | 18.95±10.01/8.99±6.37 | 19 | 24 |
| Guoying Han, 2010 | 39 | 29 | 568.6±92.5/412.5±94.7 | 581.7±102.4/483.4±107.6 | N/A | N/A | N/A | N/A | N/A | N/A |
| Min Dai, 2015 | 36 | 29 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Xiaohong He, 2008 | 27 | 20 | 508.0±63.6/276.1±23.2v | 512.2±57.6/408.3±30.9 | N/A | N/A | 56.5±10.2/17.4±5.7 | 54.9±11.5/30.6±8.3 | N/A | N/A |
| Xiaoxia Wang, 2010 | 28 | 29 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Huijuan Yao, 2010 | 51 | 52 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Lei Zhang, 2016 | 33 | 31 | 546.69±34.23/393.02±62.69 | 542.43±43.65/479.81±71.81 | N/A | N/A | 28.59±6.69/17.54±4.74 | 29.59±5.59/23.22±6.08 | 0 | 0 |
| Bo Shi, 2010 | 38 | 25 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Liping Yan, 2012 | 35 | 23 | 573.4±113.6/369.1±117.2 | 587.5±109.7/421.8±121.3 | N/A | N/A | N/A | N/A | N/A | N/A |
| Yulei Wu, 2015 | 38 | 32 | 573.7±102.9/428.5±122.5 | 582.7±112.5/368.4±117.8 | N/A | N/A | N/A | N/A | N/A | N/A |
| Yueqi Wang, 2013 | 30 | 29 | 542.36±54.55/351.12±43.92 | 534.99±58.81/424.73±56.79 | 30.90±10.15/6.70±5.11 | 31.45±10.75/12.65±5.26 | 28.90±6.53/6.74±3.14 | 29.45±11.58/7.67±4.11 | 0 | 7 |
| Rong Li, 2014 | 69 | 62 | 525.68±114.85/308.30±50.96 | 537.01±126.46/375.60±61.17 | N/A | N/A | N/A | N/A | N/A | N/A |
| Shanshan Yu, 2008 | 38 | 34 | 552.80±92.76/284.43±58.39 | 560.48±89.37/363.22±63.21 | N/A | N/A | N/A | N/A | 1 | 11 |
| Weidong Qian, 2007 | 53 | 34 | N/A | N/A | N/A | N/A | N/A | N/A | 1 | 5 |
| Zheng Huang, 2013 | 28 | 27 | 477.16±97.33/430.65±88.97 | 465.52±90.13/451.91±89.48 | N/A | N/A | N/A | N/A | N/A | N/A |
| Chongyu Tan, 2013 | 48 | 34 | 568.73±38.29/326.81±38.14 | 573.77±39.87/371.90±38.39 | N/A | N/A | N/A | N/A | 4 | 16 |
| Chun Kang, 2012 | 28 | 24 | 485.65±53.11/303.22±46.35 | 489.18±52.61/396.43±41.91 | N/A | N/A | N/A | N/A | 1 | 9 |
| Xiaowu Fan, 2013 | 48 | 38 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Jianchong Shen, 2014 | 57 | 49 | 495.99±50.73/312.78±54.03 | 485.50±47.58/378.07±50.89 | N/A | N/A | N/A | N/A | 1 | 5 |
| Guiqiong Huang, 2016 | 55 | 38 | 547.48±50.93/304.28±60.14 | 546.37±46.65/415.96±51.86 | 26.17±10.28/5.98±1.45 | 25.94±9.45/16.05±1.76 | 35.18±8.82/15.79±4.21 | 34.95±7.88/23.57±4.52 | N/A | 17 |
| Xin Ouyang, 2004 | 28 | 25 | 492.54±76.03/287.53±93.04 | 498.00±83.46/367.53±93.81 | N/A | N/A | 54.65±11.78/23.43±16.71 | 53.10±10.82/32.03±17.42 | 0 | 18 |
| Zhimin Qi, 2016 | 101 | 93 | 515.13±118.04/318.57±76.12 | 508.67±121.38/392.06±78.39 | 24.60±7.68/8.82±2.58 | 23.86±7.44/12.26±2.71 | 48.91±12.68/17.58±5.22 | 48.36±12.27/22.14±6.15 | 4 | 16 |
| Yaping Chen, 2014 | 40 | 37 | N/A | N/A | N/A | N/A | N/A | N/A | 15 | 32 |
| Demei Li, 2012 | 38 | 34 | 496±66.9/266±48.6 | 498±49.6/562±51.6 | 35.4±6.5/15.6±5.2 | 38.5±7.8/21.9±6.1 | 68.3±15.6/21.5±12.5 | 64.9±12.6/30.2±7.9 | 5 | 16 |
| Yanzhi Lin, 2009 | 28 | 22 | 506.57±119.90/352.41±79.93 | 548.70±83.98/402.42±85.53 | 8.15±1.25/4.64±0.97 | 8.52±1.23/6.32±1.09 | 32.62±13.82/17.9±5.2 | 32.40±13.93/26.4±10.87 | N/A | 17 |
| Dehe Li, 2007 | 36 | 26 | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Jun Hao, 2014 | 29 | 23 | N/A | N/A | N/A | N/A | N/A | N/A | 0 | 11 |
| Chongqing Yang, 2006 | 27 | 28 | 487.27±98.87/404.88±95.48 | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| Lin Wang, 2011 | 26 | 27 | 498.33±87.25/491.13±86.89 | 498.28±128.18/482.23±116.51 | 29.94±22.06/9.24±5.7 | 52.46±56.82/18.16±28.10 | N/A | N/A | 0 | 1 |
| Ayijiaman, 2012 | 54 | 37 | 539.16±34.49/376.3±52.85 | 552.29±46.15/425.79±48.69 | N/A | N/A | N/A | N/A | N/A | N/A |
| Chifeng Wang, 2014 | 33 | 30 | 482.5±51.3/388.3±50.4 | 481.5±50.9/420.2±55.9 | 24.4±3.6/15±2.6 | 24.34±3.7/16±2.9 | 26.3±4.3/13.6±7.2 | 26.2±4.5/15.8±6.8 | N/A | N/A |
| Jianping Luo, 2010 | N/A | N/A | 545.1±5.1/501.2±5.2 | 546.9±4.9/518.1±5 | N/A | N/A | N/A | N/A | N/A | N/A |
| Xianzhang Zeng, 2013 | 58 | 51 | 589.35±92.87/317.26±89.23 | 578.34±95.31/323.44±92.59 | N/A | N/A | N/A | N/A | N/A | N/A |
| Jinjin Jia, 2010 | 26 | 23 | 488.3±78.4/285.75±75.6 | 490.2±72.5/433.5±77.5 | N/A | N/A | N/A | N/A | 0 | 5 |
| Xiaozhong Yu, 2013 | 31 | 28 | 556±23.1/216.12.6 | 552.±21.8/221±15.2 | N/A | N/A | N/A | N/A | 1 | 15 |
| Jinfeng Li, 2013 | 34 | 33 | 468.39±100.28/342.47±90.26 | 452.28±98.75/437.65±94.57 | N/A | N/A | N/A | N/A | N/A | N/A |
aEG: experimental group, CG: control group; bSUA: serum uric acid; cCRP: C-reactive protein; dESR: Erythrocyte Sedimentation Rate; eN/A: not applicable.