Table 5.
Known-groups comparisons for the WHOQOL-BREF general facet and domain scores (n = 153)
| General Facet | Physical Health | Psychological Health | Social Relationships | Environment | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | Mean (SD) | P-value (effect size)* | n | Mean (SD) | P-value (effect size)* | n | Mean (SD) | P-value (effect size)* | n | Mean (SD) | P-value (effect size)* | n | Mean (SD) | P-value (effect size)* | |
| Number of different adverse eventsa | |||||||||||||||
| 0–5 | 84 | 6.1 (1.7) | 0.10 | 87 | 13.6 (3.1) | < 0.001 (0.08) | 87 | 14.5 (2.5) | 0.47 | 87 | 16.1 (2.7) | 0.37 | 87 | 15.8 (2.2) | 0.81 |
| more than 5 | 66 | 5.6 (1.8) | 66 | 11.8 (2.9) | 66 | 14.2 (2.6) | 66 | 16.4 (2.4) | 66 | 15.9 (2.4) | |||||
| Number of different adverse events with CTCAE grade 3 or 4a | |||||||||||||||
| 0 | 112 | 6.0 (1.8) | 0.16 | 115 | 13.1 (3.1) | 0.06 | 115 | 14.4 (2.4) | 0.93 | 115 | 16.1 (2.6) | 0.36 | 115 | 15.8 (2.3) | 0.82 |
| 1 | 27 | 6.0 (1.8) | 27 | 12.8 (3.0) | 27 | 14.4 (2.8) | 27 | 16.5 (2.6) 17.1 (2.2) |
27 | 16.0 (2.3) | |||||
| 2 or more | 11 | 4.9 (1.4) | 11 | 10.8 (2.6) | 11 | 14.7 (2.9) | 11 | 16.3 (2.5) | 11 | 16.1 (2.6) | |||||
| ECOG performance scoreb | 16.5 (2.3) | ||||||||||||||
| 0 | 37 | 6.6 (1.5) | < 0.001 (0.08) | 39 | 15.1 (2.3) | < 0.001 (0.23) | 39 | 15.1 (2.2) | 0.04 (0.04) | 39 | 14.7 (3.5) | 0.05 | 39 | 16.1 (1.8) | 0.38 |
| 1 | 98 | 5.7 (1.8) | 99 | 12.3 (3.0) | 99 | 14.3 (2.6) | 99 | 99 | 15.9 (2.5) | ||||||
| 2 or more | 13 | 4.8 (1.1) | 13 | 10.2 (2.0) | 13 | 13.1 (2.2) | 13 | 13 | 15.1 (2.3) | ||||||
| Global health status/QoL EORTC QLQ-C30 score | |||||||||||||||
| 0–50 | 67 | 4.9 (1.5) | < 0.001 (0.30) | 69 | 10.8 (2.7) | < 0.001 (0.36) | 69 | 13.1 (2.6) | < 0.001 (0.22) | 69 | 16.0 (2.8) | 0.28 | 69 | 15.1 (2.4) | < 0.001 (0.10) |
| more than 50 | 79 | 6.8 (1.4) | 80 | 14.6 (2.3) | 80 | 15.5 (1.9) | 80 | 16.5 (2.3) | 80 | 16.6 (2.0) | |||||
Abbreviations: WHOQOL-BREF World Health Organization Quality of Life-BREF questionnaire, SD standard deviation, n number of patients who completed the questionnaire, CTCAE Common Terminology Criteria for Adverse Events, ECOG Eastern Cooperative Oncology Group, QoL quality of life, EORTC QLQ-C30 European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30
P-values calculated with one-way ANOVA unless stated otherwise
*Effect sizes (η2) were only shown where one-way ANOVA was significant (P < 0.05).
aReported adverse events: as reported at and before day 1 of the first cycle of chemotherapy
bPost hoc analyses with Tukey HSD test of significant differences: for the General Facet, between ECOG 0 and 1 and also 0 and 2 or higher; for Physical Health, between all ECOG categories; for Psychological Health, between ECOG 0 and ECOG 2 or higher