Table 2.

The anti-cancer effects of major components of AL

Chemical name	Tumor suppressive effect	Potential targets	Function study	References
Atractylenolide I	Anti-bladder cancer effect	↓PI3K/Akt/mTOR	In vitro and In vivo	[17]
	Anti-leukemia effect	↑CD14/CD68	In vitro	[23]
	Anti-melanoma effect	↓p-JAK2/p-STAT3	In vitro	[25]
Atractylenolide II	Anti-melanoma effect	↓p-STAT3/p-Src	In vitro and in vivo	[33]
	Anti-gastric cancer effect	↓p-Akt/p-ERK	In vitro	[34]
Hinesol	Anti-leukemia effect	↓c-Jun	In vitro	[50]
β-Eudesmol	Anti-bile duct cancer effect	↓NQO1	In vitro and in vivo	[53, 54]
β-Sitosterol	Anti-melanoma effect	↓JNK	In vitro	[77]
	Anti-gastric cancer effect	↑PTEN/p-AMPK	In vitro and in vivo	[78]