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. 2018 Nov 23;17:167. doi: 10.1186/s12943-018-0920-z

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Prognostic significance of LINC00312 expression in combination with VM density. a Schematic presentation of typical images of CD31-/PAS+ double staining to explore correlations between LINC00312 and VMs in ADC clinical samples. b Quantitative analysis of VMs (CD31-/PAS+). c Kaplan–Meier analyses of the correlation between LINC00312 levels, VMs density and OS in the ADC patients. Patients showed worse OS when grouped by high LINC00312 expression together with high VMs. High VMs: VMs density ≥10.2; Low VMs: VMs density ≤10.2. Scale bars: 100μm in 600 x images