Table 2.

Univariate and multivariate cox hazards analysis for overall survival in 539 patients with HCC

Variables	Univariate analysis		Multivariate analysis
	Χ 2	p-Value	HR	95%CI	p-Value
Gender
Male vs. Female	0.035	0.853
Age (years)
< 53 vs. ≥ 53	0.481	0.488
TNM stage
III-IV vs. I-II	122.544	< 0.001	3.068	2.263–4.160	< 0.001
Tumor size(cm)
< 5 vs. ≥ 5	122.424	< 0.001
Tumor number
Single vs. Multiple	20.516	< 0.001
Node stage
N0 vs. N1–2	15.215	< 0.001
Distant metastases
Yes vs. No	7.140	0.008
BMI (kg/m2)
≥ 24.0 vs. 18.5–23.9 vs. < 18.5	4.454	0.108
Alcohol behavior
Previous/Current vs. Current	0.193	0.908
Family history of cancer
Yes vs. No	3.851	0.146
HBs Ag
Positive vs. Negative	0.749	0.384
HBe Ag
Positive vs. Negative	2.015	0.156
AFP (ng/mL)
< 400 vs. ≥400	27.697	< 0.001	1.710	1.292–2.264	< 0.001
TC(mmol/L)
< 4.625 vs. ≥4.625	0.241	0.624
TG(mmol/L)
< 0.615 vs. ≥0.615	0.154	0.695
HDL(mmol/L)
< 1.085 vs. ≥1.085	6.534	0.011
LDL(mmol/L)
< 2.695 vs. ≥2.695	20.524	0.469
ApoA-1(g/L)
< 1.075 vs. ≥1.075	34.756	< 0.001	0.588	0.440–0.786	< 0.001
ApoB(g/L)
< 0.635 vs. ≥0.635	0.854	0.356
CRP(mg/L)
< 6.805 vs. ≥ 6.805	73.715	< 0.001	2.056	1.491–2.834	< 0.001

Abbreviations: HR hazard ratio, 95% CI 95% confidence interval, BMI body mass index, AFP alpha fetoprotein, TC total cholesterol, TG triglycerides, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, ApoA-1 apolipoprotein A-1, ApoB apolipoprotein B, CRP C-reactive protein