Table 3.

Univariate and multivariate cox hazards analysis for Disease-free survival in 539 patients with HCC

Variables	Univariate analysis		Multivariate analysis
	Χ 2	p-Value	HR	95%CI	p-Value
Gender
Male vs. Female	0.030	0.861
Age (years)
< 53 vs. ≥ 53	0.423	0.515
TNM stage
III-IV vs. I-II	121.676	< 0.001	3.068	2.263–4.160	< 0.001
Tumor size(cm)
< 5 vs. ≥ 5	121.603	< 0.001
Tumor number
Single vs. Multiple	20.408	< 0.001
Node stage
N0 vs. N1–2	15.031	< 0.001
Distant metastases
Yes vs. No	7.069	0.008
BMI (kg/m2)
≥ 24.0 vs. 18.5–23.9 vs. < 18.5	4.431	0.109
Alcohol behavior
Previous/Current vs. Current	0.178	0.915
Family history of cancer
Yes vs. No	3.929	0.140
HBs Ag
Positive vs. Negative	0.778	0.378
HBe Ag
Positive vs. Negative	1.937	0.164
AFP (ng/mL)
< 400 vs. ≥400	28.609	< 0.001	1.710	1.292–2.264	< 0.001
TC(mmol/L)
< 5.69 vs. ≥5.69	0.182	0.670
TG(mmol/L)
< 1.7 vs. ≥1.7	0.626	0.429
HDL(mmol/L)
< 1.16 vs. ≥1.16	5.056	0.025
LDL(mmol/L)
< 3.1 vs. ≥3.1	0.292	0.589
ApoA1(g/L)
< 1.20 vs. ≥1.20	30.090	< 0.001	0.588	0.440–0.786	< 0.001
ApoB(g/L)
< 1.10 vs. ≥1.10	0.675	0.411
CRP(mg/L)
< 3.0 vs. ≥ 3.0	64.842	< 0.001	2.056	1.491–2.834	< 0.001

Abbreviations:HR hazard ratio, 95% CI 95% confidence interval, BMI body mass index, AFP alpha fetoprotein, TC total cholesterol, TG triglycerides, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, ApoA-1 apolipoprotein A-1, ApoB apolipoprotein B; CRP C-reactive protein