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. 2018 Nov 26;19:202. doi: 10.1186/s13059-018-1578-y

Fig. 2.

Fig. 2

Outline of the analysis framework with a benchmark against SVD-based methods. Results are based on in silico simulations where the ground truth with one-dimensional latent factor is known. One CNV signal is correlated with batch effect, and the other is not. CODEX2 utilizes negative control samples and negative control regions and outperforms SVD-based methods