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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Mol Immunol. 2018 Oct 20;103:312–321. doi: 10.1016/j.molimm.2018.09.019

Figure 5. ChIP-seq of the enhancer regions.

Figure 5.

MonoMac6 cells were treated with 1μg/ml LPS for 90 minutes. ChIP assays were performed with antibodies H3K4me3, H3K27ac, c-JUN and P65. In resting cells, H3K4me3 was highest at Enhancer 1. LPS stimulation let to increased c-JUN at Enhancer 1, ADAM28 promoter, H3K27ac at the ADAMDEC1 promoter and Enhancer 2 as well as binding of p65 to the ADAM28 promoter and Enhancer 2. (n=4, error bars represent SD, * indicates p<0.05, ** p<0.01).