Figure 3.

Microglial Replacement does not Alter Neuroinflammatory Gene Expression in Response to LPS. (a) Experimental design (n = 3 mice/group). (b, c) Gene expression for immune genes assessed via Nanostring Mouse Immune panel (550 genes). (b) Heatmap of differentially expressed genes between Aged Con and Aged Repop mice (adj. p < 0.05) at baseline (0 hr LPS) shown for all groups. (c) Heatmap of differentially expressed genes due to LPS at either 6 or 48 hr in Con or Aged Con mice (adj. p < 0.05) shown for all groups. Normalized raw expression values are depicted (light blue to red). All genes and values can be found in Table S1