Figure 6.

Microglial Replacement in Aged Mice Completely Reverses Impairments in Long‐Term Potentiation. (a–c) Field excitatory postsynaptic potential (fEPSPs) recordings in the CA1b stratum radiatum of hippocampal slices from young control (Con), young microglia‐repopulated (Repop), aged control (Aged Con), and aged microglia‐repopulated (Aged Repop) mice (n = 8–9 slices/group). (a) Input/output curves. (b) Paired‐pulse facilitation (PPF). (c) Long‐term potentiation (LTP) was induced using theta burst stimulation (TBS) with analysis of 70–80 min. Inset: Representative traces of field responses during baseline (solid line) and 1 hr after TBS (dotted line). Scale bar: 1 mV per, 5 ms. Data presented as means ± SEM. Comparisons for (b): ^ƱRepop versus Aged Repop