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. Author manuscript; available in PMC: 2018 Nov 28.
Published in final edited form as: J Phys Chem B. 2016 Mar 22;120(33):8080–8089. doi: 10.1021/acs.jpcb.6b00152

Figure 1:

Figure 1:

Reversible binding with stochastic gating. (A) A macromolecule fluctuates between the open, M1 (red), and closed, M2 (blue), states. A ligand L reversibly binds to the macromolecule in the open state M1 and forms a complex C. (B) A ligand fluctuates between the reactive, L1 (red), and unreactive, L2 (blue), states. The ligand in the reactive state L1 binds to the macromolecule M and forms a complex C. The open (or reactive) states are labeled by the index “1”.