Table 3.
Pooled hazard ratios (HRs) for OS according to subgroup analyses.
| Subgroup | No. of studies | No. of patients | HR (95% CI) | P value | Heterogeneity | |
|---|---|---|---|---|---|---|
| I2(%) | Ph | |||||
| Overall | 8 | 1404 | 1.38 (1.19-1.62) | <0.001 | 16.5 | 0.30 |
| Treatment | ||||||
| Surgery | 5 | 840 | 1.43 (1.12-1.83) | 0.005 | 30.8 | 0.22 |
| Chemoradiotherapy | 1 | 257 | 1.19 (0.91-1.55) | 0.200 | — | — |
| Mixed | 1 | 120 | 1.89 (1.11-3.14) | 0.020 | — | — |
| Stage | ||||||
| Mixed | 6 | 866 | 1.40 (1.18-1.67) | <0.001 | 8.2 | 0.36 |
| Metastatic | 1 | 257 | 1.19 (0.91-1.55) | 0.200 | — | — |
| Cut-off | ||||||
| ≥150 | 3 | 485 | 1.59 (1.03-2.46) | 0.036 | 56.2 | 0.102 |
| <150 | 5 | 919 | 1.33 (1.14-1.56) | <0.001 | 0 | 0.505 |
| Analysis method | ||||||
| Univariate | 2 | 430 | 1.16 (0.93-1.45) | 0.174 | 0 | 0.778 |
| Multivariate | 6 | 974 | 1.52 (1.27-1.81) | <0.001 | 0 | 0.426 |