Table 4.
Meta-analysis of the association between PLR and clinicopathological features of CCA.
| Characteristics | No. of studies | No. of patients | OR (95% CI) | p | Heterogeneity | |
|---|---|---|---|---|---|---|
| I2 (%) | Ph | |||||
| Age (≥ median vs. < median) | 3 | 669 | 0.82 (0.38-1.77) | 0.61 | 70 | 0.03 |
| Gender (male vs. female) | 4 | 789 | 0.59 (0.44-0.80) | < 0.001 | 0 | 0.94 |
| CA199 (>37 ng/mL vs. <37 ng/mL) | 3 | 669 | 1.25 (0.92-1.70) | 0.16 | 0 | 0.56 |
| Differentiation (low vs. moderate/high) | 2 | 442 | 1.05 (0.64-1.73) | 0.85 | 0 | 0.90 |
| Lymph node metastasis (pos vs. neg) | 4 | 1194 | 1.16 (0.82-1.65) | 0.39 | 0 | 0.63 |
| Vascular invasion (pos vs. neg) | 2 | 978 | 1.27 (0.86-1.89) | 0.23 | 0 | 0.56 |
| Postoperative complication (present vs. absent) | 2 | 776 | 1.44 (0.97-2.14) | 0.07 | 0 | 0.39 |
| Postoperative mortality (present vs. absent) | 2 | 776 | 1.54 (0.56-4.26) | 0.41 | 0 | 0.67 |
| Margin status (R1 vs. R0) | 2 | 776 | 2.09 (1.24-3.54) | 0.006 | 0 | 0.69 |
R0: microscopically negative resection margins; R1: microscopically positive resection margins.