Table 2.
Decreased protein expression in HT29 cells treated with organic or inorganic copper compared to control cells (2‐hr exposure, 10‐hr recovery)
| Accession | ANOVA (p) | Gene | Description | Cu Gly | Cu OAC | CuSO4 | Cu Pro |
|---|---|---|---|---|---|---|---|
| ER/UPR/Proteosomal | |||||||
| P13667 | 0.0102 | PDIA4 | Protein disulfide‐isomerase A4 | 1.3 | 1.7 | 1.8 | 1.8 |
| Trafficking | |||||||
| Q92928 | 0.0185 | RAB1C | Putative Ras‐related protein Rab‐1C | 130.5 | 3.0 | 1.9 | 148.5 |
| P02765 | 0.0332 | AHSG | Alpha‐2‐HS‐glycoprotein | 1.8 | 2.6 | 2.1 | 2.9 |
| P20073 | 0.0242 | ANXA7 | Annexin A7 | 1.2 | 1.4 | 1.5 | 1.6 |
| Cytoskeletal | |||||||
| Q15424 | 0.0072 | SAFB | Scaffold attachment factor B1 | 468.3 | 2.5 | 1.7 | 565.7 |
| P05787 | 0.0242 | KRT8 | Keratin, type II cytoskeletal 8 | 1.8 | 2.0 | 1.2 | 1.4 |
| P60709 | 0.0387 | ACTB | Actin, cytoplasmic 1 | 1.4 | 1.6 | 1.7 | 1.8 |
| P98088 | 0.0067 | MUC5AC | Mucin‐5AC | 1.9 | 2.3 | 1.8 | 2.0 |
| Apoptosis | |||||||
| Q16891 | 0.0325 | IMMT | MICOS complex subunit MIC60 | 1.4 | 1.8 | 1.5 | 1.3 |
| Translation | |||||||
| P19338 | 0.0057 | NCL | Nucleolin | 1.7 | 1.0 | 1.7 | 1.9 |
| P55884 | 0.0191 | EIF3B | Eukaryotic translation initiation factor 3B | 1.3 | 1.6 | 1.6 | 1.8 |
| P24534 | 0.0202 | EEF1B2 | Elongation factor 1‐beta | 1.3 | 1.5 | 1.4 | 1.6 |
| O00461 | 0.0021 | GOLIM4 | Golgi integral membrane protein 4 | 2.1 | 1.29 a | 1.5 | 1.4 |
| Metabolic | |||||||
| P09622 | 0.0380 | DLD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.5 | 1.7 | 1.7 | 1.9 |
| P37837 | 0.0219 | TALDO1 | Transaldolase | 1.3 | 1.5 | 1.5 | 1.7 |
| Cell cycle | |||||||
| P62714 | 0.0026 | PPP2CB | S/t‐protein phosphatase 2A catalytic subunit beta isoform | 2.3 | 1.89 a | 1.8 | 1.4 |
| A2A2Z9 | 0.0438 | ANKRD18B | Ankyrin repeat domain‐containing protein 18B | 1.6 | 1.5 | 1.9 | 1.6 |
Italic entries denote values that were not statistically significant in a paired t test with the control cells.
Values that are increased compared to control, while the rest of the results for that protein are decreased compared to control.