Table 1.

Some of resveratrol neuroprotective effect studies result in vivo and in vitro in recent years (after 2010)

Sample	Resveratrol effect	Reference
The transgenic Caenorhabditis elegans strain CL2006	Aβ aggregation↓	Regitz, Fitzenberger, Mahn, Dußling, and Wenzel (2016)
	Aβ‐induced toxicity↓
	Increased flux of proteins through the autophagy pathways and actiated proteasomal degradation↑
PC12 cells	Aβ‐induced apoptosis	Feng et al. (2013)
	SIRT‐1↑
	ROCK1↓
SAMP8 mice	SIRT‐1 and AMPK↑	Porquet et al. (2013)
	Acetylated P53↓
APP/PS1 mice (diet + resveratrol)	Activated microglia↓	Capiralla, Vingtdeux, Zhao, et al. (2012)
RAW264.7 cells	Phosphorylated IKKα, IκBα, and NF‐κB↓	Capiralla, Vingtdeux, Venkatesh, et al. (2012)
BV‐2 cells	STAT1 and STAT3 activation
Ba/F3 cells	Expression of iNO and COX‐2↓
Neocortical neurons—SAMP8 mice	SIRT‐1 expression↑	Cristòfol et al. (2012)
	Oxidative damage↓
C67BL/6J mice (diet + resveratrol)	Serum TNF‐α↓	Jeon et al. (2012)
Senescence accelerated mice	Lipid peroxidation↓	Liu, Zhang, Yang, and He (2012)
	Mitochondrial deletion
Sprague‐Dawley rat (oral administrating of resveratrol)	BDNF expression↑	Rahvar et al. (2011)
SH‐SY5Y neuroblastoma cells	Generations of Aβ‐Fe, Aβ‐Cu, and Aβ‐Zn↓	Granzotto and Zatta (2011)
Sprague–Dawley rats	Lipid peroxidation↓	Huang et al. (2011)
	Aβ aggregation in hippocampus↓
H‐SY5Y human neuroblastoma	Aβ toxicity↓	Granzotto and Zatta (2011)

BDNF: brain‐derived neurotrophic factor; ↓: decrease or down‐regulation; ↑: increase or up‐regulation; inhibition.