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. 2018 Oct 26;6(8):2473–2490. doi: 10.1002/fsn3.855

Table 2.

Effect of resveratrol and its derivatives on the leishmania

Leishmanicidal effect of synthetic trans‐resveratrol analogs (Passos et al., 2015)
Resveratrol analogs IC50 promastigotes (μM) IC50 amastigotes (μM)
Pterostilbene 17.7 32.2
Piceatannol 65.0 45.0
Polydatin 95.5 29.0
Oxyresveratrol 65.0 30.5
Piceatannol analog also:

  • Increased fivefold the promastigotes in the sub‐G0 stage and decreased 1.7‐fold in G0–G1 phase

  • Changed mitochondrial membrane potential (ΔΨm)

  • Increased number of annexin‐V‐positive promastigotes

IC50: inhibitor concentration.