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C-1027 BGCs residing on giant plasmids of varying size in the five C-1027 producers. (A) PFGE analysis of the five C-1027 producers showing the existence of giant plasmids of varying sizes. (B) Southern analysis revealing that the C-1027 BGCs all reside on giant plasmids in the five producers. M, Lambda PFG ladder (NEB); lane 1,S. globisporus wild-type; lane 2, S. globisporus AF40; lane 3, CB00657; lane 4, CB02329; lane 5, CB02366; and lane 6, CB03608.
