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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Biotechnol Bioeng. 2018 Sep 6;115(11):2793–2806. doi: 10.1002/bit.26778

Figure 1:

Figure 1:

Design of platform and fabrication of single vessel microfluidic collagen platform and perfusion setup. (a) CAD design of PDMS mold and PDMS tissue chamber with 22G inlets. (b) Machined aluminium mold, PDMS chamber produced from aluminium mold and glass. (c) Tissue chamber filled with collagen around a 22G needle. (d) Collagen hydrogel with channel after polymerization and removal of needle. (e) Setup of syringe pump flow system with bubble traps for perfusion through the hydrogel. (f) Close-up view of platform with 0.5” 22G needles inserted into the chamber inlet and outlet for preconditioning.