Table 3.
Hippocampal Subfield Volume Association with PTSD Excluding Ipsilateral Whole Hippocampal Volume Covariate
| Hippocampal Subfield | Control Mean ± SD | PTSD Mean ± SD | F-Stat | p-value | age | gender | Child trauma | TLEQ | CES | BDI | AUDIT | 5-HT | Scanner | TIV |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| a priori hypotdesized regions | ||||||||||||||
| L CA1 | 627.5±78.7 | 612.2±66.1 | 3.32 | .07 | ns | .001 | ns | ns | ns | ns | ns | ns | .04 | .0001 |
| R CA1 | 649.2± 85.1 | 639.0± 72.5 | .36 | .55 | ns | .08 | ns | ns | ns | ns | ns | ns | .05 | ns |
| L CA3 | 217.5± 31.6 | 214.8± 33.1 | .07 | .79 | ns | .11 | ns | ns | ns | ns | ns | ns | .03 | .0001 |
| R CA3 | 235.6±31.5 | 233.5±30.8 | .23 | .63 | ns | ns | ns | ns | ns | ns | ns | ns | .06 | .0001 |
| L DG | 304.4± 33.3 | 299.9± 33.0 | .96 | .33 | ns | .004 | ns | ns | ns | ns | ns | ns | .02 | .0001 |
| R DG | 317.7±35.9 | 313.7±33.1 | .01 | .91 | ns | ns | ns | ns | ns | ns | ns | ns | .002 | .0001 |
| non-hypothesized regions | ||||||||||||||
| L tail | 558.5±70.8 | 555.5±64.4 | .54 | .46 | ns | .05 | ns | ns | ns | ns | ns | ns | .01 | .0001 |
| R tail | 563.2± 76.5 | 557.8± 69.4 | .38 | .54 | ns | .02 | ns | ns | ns | ns | ns | ns | .03 | .08 |
| L subiculum | 431.8±54.7 | 426.7±46.0 | .19 | .66 | ns | ns | ns | ns | ns | ns | ns | ns | ns | .0001 |
| R subiculum | 429.1± 49.8 | 421.9± 41.5 | 1.29 | .26 | ns | ns | ns | ns | ns | ns | ns | ns | .01 | .0001 |
| L fissure | 149.5±28.7 | 148.1± 24.4 | .10 | .76 | .07 | ns | ns | ns | ns | ns | ns | ns | .05 | 0001 |
| R fissure | 154.6±27.2 | 155.4±24.9 | .37 | .55 | .004 | ns | ns | ns | ns | ns | ns | ns | .04 | .0001 |
| L presubiculum | 314.6± 40.0 | 310.4± 37.6 | .36 | .55 | ns | .02 | ns | ns | ns | ns | ns | ns | .01 | .0001 |
| R presubiculum | 297.9± 35.5 | 290.9± 33.7 | 1.68 | .20 | ns | .01 | ns | ns | ns | ns | ns | ns | .001 | .0001 |
| L parasubiculum | 66.4± 11.26 | 63.4± 10.6 | 4.50 | .04 | .08 | .10 | ns | ns | ns | ns | ns | ns | ns | .0001 |
| R parasubiculum | 63.2± 10.3 | 60.6± 10.6 | 5.16 | .02 | .05 | ns | ns | ns | ns | ns | ns | ns | ns | .0001 |
| L molecular layer | 576.1± 66.6 | 564.0± 57.1 | 2.10 | .15 | ns | .01 | ns | ns | ns | ns | ns | ns | .01 | .0001 |
| R molecular layer | 589.4± 65.2 | 578.3± 55.1 | .95 | .33 | ns | .13 | ns | ns | ns | ns | ns | ns | .01 | .0001 |
| L CA4 | 261.9± 29.0 | 258.7± 28.7 | .42 | .52 | ns | .01 | ns | ns | ns | ns | ns | ns | .06 | .0001 |
| R CA4 | 274.6±30.8 | 271.7± 29.2 | .00 | .99 | ns | ns | ns | ns | ns | ns | ns | ns | .002 | .0001 |
| L fimbria | 80.1± 19.5 | 78.1± 20.3 | .60 | .44 | .01 | .001 | ns | ns | ns | ns | ns | ns | .0001 | .0001 |
| R fimbria | 78.3 ±19.3 | 79.3±19.5 | .08 | .78 | .001 | .01 | ns | ns | ns | ns | ns | ns | .0001 | ns |
| L HATA | 64.0± 9.2 | 63.6±10.5 | .13 | .72 | .06 | .005 | ns | ns | ns | ns | ns | ns | .001 | .0001 |
| R HATA | 62.5±10.2 | 62.2±10.3 | .04 | .84 | .07 | .05 | ns | ns | ns | ns | ns | ns | .0001 | .0001 |