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Optimal ratio determination for cGAMP and resiquimod (R848) microparticles. Bone marrow derived dendritic cells from C57BL/6 mice were treated for 22 h with indicated concentrations of resiquimod (R848) and cGAMP, both of which were individually encapsulated within acetalated dextran (Ace-DEX) microparticles. Supernatants were analyzed for (A) IL-6, (B) TNF, (C) IL-1β, (D) IL-12p70, and (E) IFN-β. Data are presented as mean ± SEM (n = 4).
