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. Author manuscript; available in PMC: 2019 Nov 5.
Published in final edited form as: Mol Pharm. 2018 Oct 15;15(11):4933–4946. doi: 10.1021/acs.molpharmaceut.8b00579

Figure 7.

Figure 7.

Comparison of antibody responses induced by cGAMP and R848 delivered via acetalated dextran (Ace-DEX) or poly(lactic-co-glycolic acid) (PLGA) microparticles (MPs). C57BL/6 mice were immunized intramuscularly on days 0 and 21. All groups received 10 μg of OVA, except the PBS group. OVA was given alone or in combination with cGAMP (200 ng) and R848 (18 ng) delivered in single-loaded or dual-loaded Ace-DEX or PLGA MPs, blank Ace-DEX or PLGA MPs, or alum. On day 28, serum was collected and analyzed for ovalbumin (OVA)-specific (A) total IgG, (B) IgG1, and (C) IgG2c as well as (D) the ratio between IgG2c and IgG1 isotypes (n = 4–5 ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001). Data are presented as n = 5 ± SD.