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Encapsulation Efficiencies (EE) of cGAMP, Resiquimod (R848), or a Combination of Both (cGAMP/R848) within Acetalated Dextran (Ace-DEX) or Poly Lactic-co-glycolic Acid (PLGA) Microparticles by Emulsion and Electrospray
| fabrication technique |
microparticles | cGAMP EE (%) |
R848 EE (%) |
|---|---|---|---|
| emulsion | cGAMP Ace-DEX | 52 | -- |
| cGAMP PLGA | 3 | -- | |
| R848 Ace-DEX | -- | 8 | |
| R848 PLGA | -- | 0 | |
| cGAMP/R848 Ace-DEX | 25 | 8 | |
| electrospray | cGAMP Ace-DEX | 94 | -- |
| R848 Ace-DEX | -- | 86 | |
| cGAMP/R848 Ace-DEX | 83 | 75 | |
| cGAMP/R848 PLGA | 74 | 67 |
