TABLE 1.
Characteristics of Study Participants at Enrollment (Time of Serum Collection)
| Characteristics | All, N = 200 |
Confirmed TB, N = 40 |
Unconfirmed TB, N = 80 |
Unlikely TB, N = 80 | |
|---|---|---|---|---|---|
|
| |||||
| TST-Negative, N = 41 |
TST-Positive, N = 39 |
||||
| Demographics | |||||
| Median age (months) (IQR) | 41 (24–66) | 50 (27–91) | 42 (26–66) | 22 (17–41) | 49 (31–61) |
| Age range (months) | 12–152 | 16–147 | 12–143 | 12–152 | 13–150 |
| Age 12–60 (months) | 136 (68) | 23 (58) | 52 (65) | 33 (80) | 28 (72) |
| Age ≥60 (months) | 64 (32) | 17(42) | 28(35) | 8 (20) | 11 (28) |
| Male, N (%) | 97 (49) | 21 (53) | 39 (49) | 21 (51) | 16 (41) |
| Household TB contact*, N (%) | 135 (69) | 24 (60) | 53 (69) | 22 (54) | 36 (92) |
| TB symptoms and signs | |||||
| Cough or other respiratory symptoms, N (%) | 160 (80) | 31 (78) | 61 (76) | 38 (93) | 30 (77) |
| Median cough duration (days) (IQR) | 14 (7–29) | 14 (7–14) | 14 (6–30) | 14 (3–30) | 14 (14–21) |
| Fever, N (%) | 105 (53) | 21 (53) | 49 (61) | 21 (51) | 14 (36) |
| Median fever duration (days) (IQR) | 7 (3–14) | 14 (7–14) | 5 (3–7) | 5 (3–14) | 11 (7–14) |
| Night sweats, N (%) | 116 (58) | 22 (55) | 51 (64) | 20 (49) | 23 (59) |
| Median night sweats duration (days) (IQR) | 14 (7–30) | 14 (7–28) | 14 (7–30) | 26 (7–60) | 14 (14–30) |
| Weight loss, N (%) | 128 (64) | 28 (70) | 50 (63) | 31 (76) | 19 (49) |
| Median days of weight loss (IQR) | 30 (14–31) | 30 (14–60) | 30 (14–31) | 30 (14–45) | 30 (18–31) |
| Results of diagnostic testing, N (%) | |||||
| TST positive† | 134 (68) | 28 (76) | 67 (84) | 0 (0) | 39 (100) |
| Culture-positive for Mycobacterium tuberculosis from respiratory sample | 40 (20) | 40 (100) | 0 (0) | 0 (0) | 0 (0) |
| Xpert MTB/RIF positive for M. tuberculosis from respiratory sample | 27 (14) | 23 (58) | 4 (5) | 0 (0) | 0 (0) |
| Chest radiograph suggestive of pulmonary TB‡ | 39 (40) | 12 (31) | 15 (23) | 4 (11) | 3 (8) |
*
N = 197 (3 recorded as not known).
†
N = 197 (TST not administered or not read for 3 participants).
‡
N = 178.