Table 1:
Participants characteristics
| Variables | Young adults (n=165) | Older adults (n=40) | Older adults subset with PWV (n=24) | p-value (young vs. older, n=40) | p-value (young vs. older subset, n=24) |
|---|---|---|---|---|---|
| Males/Females, n/n | 99/66 | 29/11 | 16/8 | 0.128 | 0.361 |
| Age (years) | 22.6 ± 0.3 | 68.0 ± 1.6* | 70.0 ± 2.0ψ | <0.001 | <0.001 |
| BMI (kg/m2) | 25.7 ± 0.3 | 27.8 ± 0.7* | 26.5 ± 0.7 | 0.003 | 0.359 |
| Education (years) | - | - | 15.9 ± 0.5 | - | - |
| Atherosclerotic Vascular Disease, n (%) | - | - | 5 (21.7) | - | - |
| Mild Cognitive Impairment, n (%) | - | - | 2 (8.3) | - | |
| Anti-hypertensive medication, n (%) | - | - | 7 (30.4) | - | - |
| Aspirin therapy, n (%) | - | - | 9 (39.1) | - | - |
| Statin, n (%) | - | - | 6 (26.1) | - | - |
| Blood Pressure and Vascular Outcomes | |||||
| Brachial systolic BP (mmHg) | 117.1 ± 2.5 | - | - | ||
| Brachial diastolic BP (mmHg) | 62.8 ± 1.3 | - | - | ||
| Brachial pulse pressure (mmHg) | 54.2 ± 2.6 | - | |||
| Carotid-femoral PWV (m/sec) | - | - | 10.1 ± 0.5 | - | - |
| Carotid-femoral PWV adjusted for delay between neuroimaging and vascular visits (m/sec) | - | - | 10.2 ± 0.5 | - | - |
| Cerebral blood flow | |||||
| Basal global CBF (mL/min/100mL of tissue) | 50.5 ± 0.7 | 36.5 ± 1.1* | 35.2 ± 1.5ψ | <0.001 | <0.001 |
| ACZ flow (mL/min/100mL of tissue) | - | - | 47.2 ± 1.8 | - | - |
| AbsCVR (mL/min/100mL of tissue) | - | - | 11.6 ± 1.2 | - | - |
| RelCVR (%) | - | - | 36.1 ± 3.4 | - | - |
| Cognitive Performance | |||||
| Mini Mental Status Exam | - | - | 28.9 ± 0.4 | - | - |
Data are mean ± SE. BMI, body mass index; BP, blood pressure; PWV, pulse wave velocity; CBF, cerebral blood flow; ACZ, acetazolamide; AbsCVR, absolute cerebrovascular reserve; RelCVR, relative cerebrovascular reserve. Brachial blood pressures and cfPWV were available in n=19 and n=24 participants, respectively.
*
denotes p<0.05 older (n=40) vs. young;
ψ
denotes p<0.05 subset of older with PWV (n=24) vs. young.