| Temazepam |
Onset: PO 0.5–2 h Tmax: 1.2–1.6 h |
3.5–18.4 h |
10 mg |
Slow onset Intermediate acting Low potency No active metabolites Preferred in liver disease |
| Diazepam |
Onset: IV 4–5 min Tmax: IV 1 min, IM 1 h, PO 15 min-2.5 h |
IV: 33–45 h PO: 44–48 h PR: 45–46 h |
5 mg |
Fast onset Long acting Low potency Higher risk of abuse |
| Alprazolam |
Onset: PO 1 h Tmax: PO 1–2 h |
PO: 11–15 h |
0.5 mg |
Intermediate onset Intermediate acting High potency Higher risk of abuse |
| Clonazepam |
Onset: PO 20–40 min Tmax: PO 1–4 h |
17–60 h |
0.25 mg |
Fast onset Long acting High potency Partial serotonin agonist |
| Lorazepam |
Onset: IV 2–3 min Tmax: PO 2 h, IM ≤3 h, SL 1 h |
IV: 14 h IM: 13–18 h PO: 10 h |
1 mg |
Fast onset Short acting High potency Higher risk of abuse No active metabolites Preferred in liver disease |
| Midazolam |
Onset: IV 3–5 min, IM 15 min, PO 10–20 min Tmax: IM 0.5–1 h, PO 0.17–2.65 h |
3 h |
2 mg |
Fast onset Ultra short acting Intermediate potency Shortest half life |
