Table 3:
Immunological profile of stroke patients who did and did not receive rt-PA treatment
| Analyte | No rt-PA (pg/ml) [n=9] | rt- PA (pg/ml) [n=13] | p-value |
|---|---|---|---|
| APRIL/TNFSF13 | 119079 (90590-208421) | 93130 (66009-148935) | 0.21 |
| BAFF/TNFSF13B | 4558 (3471-6308) | 4551 (2912 – 5913) | 0.30 |
| Chitinase 3-like 1 | 13597 (9719 – 1445) | 9770 (7778 – 11844) | 0.21 |
| gp130/sIL-6Rβ | 36834 (16714 – 38900) | 26096 (20324 – 42258) | 0.90 |
| IFN-α2 | 8.93 (7.78 – 11.09) [7] | 5.53 (3.14 – 7.169) [10] | 0.031 |
| IFN-β | 26.25 (22.53 – 37.18) | 23.13 (20.23 – 31.13) | 0.29 |
| IFN-γ | 10.88 (5.765 – 13.18) | 8.357 (5.458 – 9.67) | 0.23 |
| IL-2 | 1.14 (0.97 – 1.8) [7] | 0.79 (0.3163 – 1.14) [6] | 0.047 |
| IL-8 | 13.66 (6.968 – 20.02) | 9.41 (7.432 – 13.66) [11] | 0.49 |
| IL-10 | 0.25 (0.23 – 0.27) [2] | 0.8295 (0.309 – 1.35) [2] | 0.33 |
| IL-11 | 1.13 (0.9595 – 1.625) | 0.9621 (0.7554 – 1.12) | 0.13 |
| IL-12(p40) | 17.45 (14.47 – 22.11) | 15 (13.49 – 17.21) | 0.23 |
| IL-12(p70) | 0.17 (0.085 – 0.4125) | 0.1225 (0.06492 – 0.18) | 0.93 |
| IL-19 | 3.105 (0.89 - 11.79) [4] | none | n/a |
| IL-20 | 25.27 (12.61 – 31.27) [8] | 16.13 (10.54 – 20.14) [11] | 0.10 |
| IL-22 | n/a | n/a | n/a |
| IL-26 | 3.586 (2.259 – 4.815) | 3.317 (2.195 – 3.86) | 0.64 |
| IL-27(p28) | n/a | ||
| IL-28A/IFN-λ2 | 16.25 (11.62 – 23.35) | 14.01 (9.525 – 17) | 0.20 |
| IL-29/IFN-λ1 | 8.995 (2.558 – 15.69) [6] | 3.35 (2.08 – 3.35) [3] | 0.25 |
| IL-32 | n/a | n/a | n/a |
| IL-34 | n/a | n/a | n/a |
| IL-35 | 25.95 (19.24 – 30.35) [8] | 17.79 (4.881 – 20.87) [7] | 0.067 |
| LIGHT/TNFSF14 | n/a | n/a | n/a |
| MMP-1 | 771.2 (484.7 – 1138) [5] | 304.5 (169.8 – 917.5) [8] | 0.12 |
| MMP-2 | 4334 (4216 – 5317) | 2571 (1548 – 6242) | 0.56 |
| MMP-3 | 3872 (2830 – 6253) [8] | 3889 (1692 – 5352) [12] | 0.58 |
| Osteocalcin | 572.7 (411.1 – 829.1) | 459.9 (349.6 – 1187) | 0.60 |
| Osteopontin (OPN) | 7737 (2730 – 10029) | 6125 (3421 – 10572) | 0.74 |
| Pentraxin-3 | 73.43 (26.82 – 406.5) [4] | 1.426 (0.2529 – 5.232) [4] | 0.029 |
| SCD30/TNFRSF8 | 229.1 (163.5 – 359.7) | 221.1 (160.8 – 275.8) | >0.9999 |
| sCD163 | 613.3 (487.1 – 935.1) | 653 (482.8 – 768.9) | 0.90 |
| sIL-6Rα | 4951 (3480 – 5986) | 3987 (3351 – 4899) | 0.19 |
| sTNF-R1 | 1202 (823.5 – 1535) | 931.6 (718.7 – 1184) | 0.36 |
| STNF-R2 | 7878 (4431 – 12026) | 8002 (6558 – 11497) | >0.9999 |
| TSLP | 12.72 (9.209 – 19.8) | 10.26 (9.849 – 12.46) | 0.36 |
| TWEAK/TNFSF12 | 133.8 (110 – 164.6) | 127.8 (99 – 160.1) | 0.44 |
Median values and interquartile ranges (IQR) shown; all values in pg/ml
*
only expressed in a subset of samples, n # shown italicized in square brackets
†
Biomarker is below detection level in stroke and control samples
Significant p-vales bold