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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Exp Neurol. 2018 Apr 10;305:121–128. doi: 10.1016/j.expneurol.2018.04.007

Figure 1. Basal extracellular K+ influences sensitivity to ketamine.

Figure 1.

A: Representative intrinsic optical signals showing SD propagation through the hippocampal CA1 region of a brain slice. SD was triggered by micro injection of KCl from a micropipette on the left (labeled “KCl”) and SD is visualized as a slowly-propagating wave of increased light transmission. The location of the advancing wavefront is marked by white arrowheads and a second microelectrode (labeled “DC”) was used to confirm electrical responses of SD coincident with arrival of the optical signal (not shown). The upper right-hand values indicate time, in seconds, relative to the triggering of the KCl stimulus pulse. B: Effect of ketamine exposures on SD incidence under two different recording conditions (3mM vs 8mM bathing K+). Ketamine more potently prevented SD incidence in the lower basal K+ recording conditions. Values in parenthesis indicate number of preparations.