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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Exp Neurol. 2018 Apr 10;305:121–128. doi: 10.1016/j.expneurol.2018.04.007

Figure 2. Ketamine reduced SD propagation rate and DC shift duration.

Figure 2.

A: Representative example of effect of ketamine wash-in, during a series of repetitive SDs. Top panels show intrinsic optical signal changes to track SD propagation (as described in Figure 1) in control conditions (left), and during the third SD evoked in the presence of 30 μM ketamine (right). Note the delayed propagation of the SD wavefront in ketamine. The traces show DC potential recordings during this sequence of SDs in the same slice. Black arrowheads indicate DC shift onset, and dashed lines represent 15 minutes recovery between stimulations. The duration of the DC shift of SD was progressively reduced, and then recovered after ketamine washout. B: Summary data from 9 preparations as shown in A, demonstrating progressive decreases in both propagation rate and DC duration with partial recovery upon ketamine wash out in 6 experiments (gray bar). *P<.05, **P<0.01, ***P<0.001, **** P<0.0001.